Interferon-γ1b for the treatment of idiopathic pulmonary fibrosis

D Bouros, KM Antoniou, A Tzouvelekis… - … on Biological Therapy, 2006 - Taylor & Francis
… The reason for this is that IFN-γ 1b has the ability to modulate the Th1/… in all 9 patients receiving
IFN-γ 1b plus prednisolone. Three … In order to evaluate the role of Th1 cytokines and their …

[HTML][HTML] Corticosteroid and immunomodulatory agents in idiopathic pulmonary fibrosis

F Luppi, S Cerri, B Beghè, LM Fabbri, L Richeldi - Respiratory medicine, 2004 - Elsevier
… strategy should point to modulation of epithelial cell activation… relative deficits in IFN-γ
compared with Th2 cytokines.33, 34 … nine patients treated with IFN-γ-1b in addition to prednisolone

[HTML][HTML] A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis

G Raghu, KK Brown, WZ Bradford… - … England Journal of …, 2004 - Mass Medical Soc
… that was unresponsive to corticosteroid therapy to receive … with antiinflammatory and
immunosuppressive therapies such as … therapy inhibits the expression of these profibrotic …

Interferon-γ 1b: impact of new indications (idiopathic pulmonary fibrosis)

AN Aggarwal, D Behera - Expert Opinion on Pharmacotherapy, 2000 - Taylor & Francis
… of patients treated with IFN-γ and low-dose corticosteroids. … It has been proposed that
modulation of the fibrotic response … diminished IFN-γ may moderate the balance of cytokines in …

Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

EH Alhamad, JG Cal, Z Shakoor, A Almogren… - BMC medical …, 2013 - Springer
IL-6, IL-10, interferon gamma (IFN-γ), TNF-α, and TGF-β 1 … None of the patients was
receiving any corticosteroids or … IFN-γ is a Th-1 cytokine that plays pivotal roles in modulating

Therapeutic management of idiopathic pulmonary fibrosis: an evidence-based approach

SD Nathan - Clinics in chest medicine, 2006 - chestmed.theclinics.com
… expression of various profibrotic cytokines and growth factors … the group treated with IFN
γ-1b plus prednisolone, whereas … studies of IFN γ-1b therapy in IPF involving 390 patients with …

Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis

M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu… - … cell research & therapy, 2016 - Springer
… -inflammatory/fibrotic cytokines, including IL-6, IFN-γ, TNFα, … -ILD patients who had not
received corticosteroid therapy (n = … To investigate the role of human MSCs in the modulation of …

Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis

C Agostini, C Gurrieri - Proceedings of the American Thoracic …, 2006 - atsjournals.org
… influenced by steroids and/or by immunosuppressive agents. … levels after IFN-γ-1b treatment,
suggesting that IFN-γ- 1b affects IPF … , including IFN-γ, able to modulate cytokine/chemokine …

Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis

KM Antoniou, A Pataka, D Bouros… - Pulmonary pharmacology …, 2007 - Elsevier
… of IFN-γ-1b in the treatment of IPF. A meta-analysis of 390 … for IPF for its ability to modulate
the Th1/Th2 imbalance and to … , 12, 18, IFN-γ) and Th2 (IL-4, 5, 10, 13) cytokines in fibrosis are …

Current and future therapeutic approaches in idiopathic pulmonary fibrosis

D Bouros, KM Antoniou - European Respiratory Journal, 2005 - Eur Respiratory Soc
IFN-γ is an inflammatory cytokine with a number of inhibitory … better response to
immunosuppressive and corticosteroid therapy, it … Cytoskeletal protein modulation in pulmonary